Study on the Effects of Intra-Ovarian Injection of Autologous Platelet-Rich Plasma
Introduction
Transcription of the article published on June 5, 2020, from the journal AGING.
The conducted study aimed to determine if intra-ovarian injection of autologous platelet-rich plasma (PRP) improves ovarian stimulation response and in vitro fertilization outcomes in women with primary ovarian insufficiency (POI).
Methods
A total of 311 women, aged 24 to 40, who received a diagnosis of POI based on ESHRE criteria, underwent intra-ovarian injection of PRP.
Markers of ovarian reserve and IVF outcome parameters were monitored.
PRP treatment resulted in an increase in the number of antral follicles and serum anti-Müllerian hormone, while serum follicle-stimulating hormone did not change significantly.
Results
After PRP injection, 23 women (7.4%) conceived spontaneously, 201 (64.8%) developed one or more antral follicles and attempted IVF, and 87 (27.8%) had no antral follicles and therefore did not receive additional treatment.
Among the 201 women who attempted IVF, 82 (26.4% of the total) developed embryos.
25 of these women chose to cryopreserve the embryos for future transfer, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8% per transfer, 4% of the total).
In total, out of the 311 women treated with PRP, 25 (8.0%) achieved a live birth/sustained implantation (spontaneously or after IVF), while another 25 (8.0%) embryos were cryopreserved.
Conclusions
Our results suggest that in women with POI, intra-ovarian injection of autologous PRP could be considered as an experimental therapeutic alternative.
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