Introduction

Transcription of the article from Biomedical Materials, published on June 20, 2020:

Scientists are focusing on the development of personalized and tissue-specific bio-inks for 3D bioprinting technologies. Platelet-rich plasma is a person-specific source used as a therapeutic complement for cartilage injury treatment, providing a cocktail of growth factors necessary for wound healing and tissue regeneration.

Scientist handling PRP

Methods

In this study, PRP was introduced as a photo-activated and photo-crosslinkable bio-ink for tissue-specific structures for the first time. Long-term and constant growth factor release while preserving PRP bioactivity with satisfactory mechanical properties was achieved. The photo-crosslinked PRP hydrogel was activated by microwave-induced methacrylated gelatin (Mw-Gel-MA) and chemically crosslinked upon UV irradiation (300-500 nm). PRP photoactivation was carried out using a polychromatic light source in the near-infrared region (PAC, 600-1200 nm).

Results

Gel-MA/PRP hydrogels with desired mechanical properties released growth factors at a constant rate over the long term through periodic PAC application. In vitro cell culture studies proved that the proliferation and differentiation of ATDC5 cells increased in the periodically applied Gel-MA/PRP hydrogel without any external chemical agents.

Share this content

Related posts

Warning!

This website is restricted to healthcare professionals