Sustained Release of Growth Factors from Photoactivated PRP Plasma

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Published : 03/22/2021

Table of contents

Introduction
Methods
Results
Conclusions

Introduction

Transcription of the article from the European Journal of Pharmaceutics and Biopharmaceutics, published on November 30, 2019

The purpose of this study is to specify the capacity of the polychromatic light source (PAC), providing effective wavelengths in the range of 600-1200 nm (near-infrared region, NIR), to activate human platelets in PRP and achieve sustained and controlled release of growth factors from photoactivated platelets.

Methods

PRP was isolated from human blood and treated with PAC at different time intervals for 1, 5, and 10 minutes at a distance of 10 cm from the platelets. ATP secretion, followed by calcium release from the platelets, significantly increased after light application.

Results

Photostimulation of platelets triggered lamellipodia extension, numerous filopodia formation, and platelet aggregation as activation indicators. P-selectin expression was significantly increased after PAC application.

Conclusions

PRP was successfully activated with PAC for 10 minutes and achieved sustained activation-dependent growth factor release for 28 days. PAC enables sustained growth factor release from PRP with periodic use for therapeutic applications.