PRP is used in the management of various inflammatory and functional urological conditions, including interstitial cystitis, chronic urethritis, prostatitis and inflammatory diseases of the lower urinary tract.

Clinical studies report longer remission periods, reduced duration of associated antimicrobial treatments and accelerated regeneration of the urothelial mucosa. From 1 to 2 sessions onwards, practitioners frequently observe a decrease in pollakiuria, resolution of haematuria and a reduction in mucosal ulceration.

Clinical Objectives

• Promote regeneration of the bladder mucosa
• Contribute to dysuria reduction within a multidisciplinary follow-up
• Extend the remission period in chronic conditions
• Reduce the duration of associated antimicrobial therapy
• Improve quality-of-life scores (IPSS, USP)

Documented Indications

• Interstitial cystitis
• Chronic urethritis
• Chronic prostatitis
• Erectile dysfunction (vascular origin)
• Peyronie's disease
• Post-surgical stress urinary incontinence

• Drug therapy (antibiotics, anti-inflammatory agents)
• Physiotherapy (low-level laser therapy, electrophoresis)

• Ozone therapy
• Immunomodulation

Vascular erectile dysfunction is an emerging indication for PRP. The mechanisms proposed include stimulation of neoangiogenesis and regeneration of smooth muscle and nerve fibres involved in the erectile process.

Recent publications report, after several sessions, an improvement in erectile scores (IIEF) and a reduction in associated pain syndrome in certain indications. This protocol forms part of a multimodal approach and does not replace a full urological assessment.

Stress urinary incontinence following radical prostatectomy most often results from sphincter injury. Peri-sphincteric injections of autologous PRP aim to regenerate weakened muscle fibres and restore the continence function of the external urethral sphincter.

The same principle applies to anal incontinence due to sphincter injury, where peri-anal PRP injections are documented in the specialist literature.

Chronic urethritis, whether infectious or inflammatory in origin, is a documented indication for PRP. Regeneration of the urethral mucosa by growth factors may contribute to reduced pollakiuria and resolution of haematuria.

Return to normal activities is generally rapid following the procedure. Symptomatic improvement is documented after several sessions in the available literature. The standard contra-indication to baths and saunas in the 24 to 48 hours following injection should be communicated to the patient.